Participating Databases

U.S. EPA Aggregated Computational Toxicology Resource Go to external website

Type of information that can be found via eChemPortal:

ACToR contains publically available chemical toxicity data, including test data, hazard, risk, and exposure assessments, and use information.

General information

ACToR is EPA's online warehouse of all publicly available chemical toxicity data and can be used to find all publicly available data about potential chemical risks to human health and the environment. ACToR aggregates data from over 500 public sources on over 500,000 environmental chemicals searchable by chemical name, other identifiers and by chemical structure. ACToR contains information about chemical properties, hazard and exposure information, risk management, chemical usage, and toxicity.  

ACToR compiles data (both quantitative and qualitative) from a large number of sources (called data collections), including EPA databases, PubChem, other NIH and FDA databases, state and other national sources, and from academic groups. One novel data collection is ToxRefDB, which includes detailed information on in vivo guideline study results for pesticides and other potentially toxic chemicals that has been assembled by the National Center of Computational Toxicology. ACToR is also the primary respository of data being produced by the EPA ToxCast chemical prioritization program.

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Disclaimer for Information available in Actor

With respect to documents available from this server, neither the United States Government nor any of their employees, makes any warranty, express or implied, including the warranties of merchantability and fitness for a particular purpose, or assumes any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represents that its use would not infringe privately owned rights.

When using the ACToR database you accept its disclaimer:

Hazard information

ACToR incorporates chemical hazard information from a variety of sources, including US federal agencies such as the CDC, FDA, DOD, EPA, NIH, NOAA, OSHA, USDA, and USGS, as well as state level agencies such as the California EPA It also includes datasets from  ECHA,  Environment and Health Canada, the Danish EPA, and the Australian Department of Sustainability, Environment, Water, Population, and Communities. Hazard information published by NGOs (eg. EWG) and other similar groups is available as well. For a full listing of hazard data, see under the ‘Hazard’ Category.

Search capabilities

ACToR is searchable by chemical name, CASRN, or structure. Users may browse assays by toxicity, category, or data collection.


ACToR is maintained the US EPA’s NCCT.

Peer review

ACToR itself is not peer reviewed; ACToR only contains publically available datasets which have been previously published.

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